The UBE2D1 Antibody (C-term) from MyBioSource.com is a Rabbit Polyclonal antibody to SFT, UbcH5, UBCH5A, and UBE2D1. This antibody recognizes Human, Mouse, and Rat antigen. The UBE2D1 Antibody (C-term) has been validated for the following applications: ELISA, Immunohistochemistry, and Western Blot.
Description
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. UBE2D1 is a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases